Structure of p73 DNA-binding domain tetramer modulates p73 transactivation
نویسندگان
چکیده
منابع مشابه
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73 DNA-binding domain tetramer bound to response elements with spacers of different length. The str...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1115463109